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It doesn't override thermodynamics

Cys151 residue is required to inhibit Keap1-mediated Nrf2 degradation, thus itaconate upregulates Nrf2 levels via Keap1 alkylation ( Figure 3 )

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Chronobiology International, 1 , 121126

and his first was a mobile app platform funded by Softbank, which resulted in a case study published by Stanford University Press, and was taught in multiple MBA programs for a decade